C-Murder will remain in prison to serve out his life sentence.
The Supreme Court has denied C-Murder's appeal of a murder conviction, a last-ditch effort to spring the rapper from prison.
US News reports that the court rejected the appeal, which stemmed from C-Murder killing a 16-year-old fan in Louisiana.
C-Murder's attorneys argued that because federal juries must reach unanimous verdicts in criminal cases C-Murder should not have been convicted. A jury voted 10-2 to convict the rapper.
However, Louisiana is one of two states that allow for non-unanimous convictions.
C-Murder was sentenced to life in prison in 2009 for shooting and killing Steve Thomas at a nightclub in 2002. Lawyers for C-Murder, who is Master P's brother, filed an appeal in Louisiana in 2011. The conviction and life sentence were upheld in the Louisiana appeals court months later. He later filed to the Supreme Court, which delayed a ruling on the case in 2012.